期刊
MOLECULAR HUMAN REPRODUCTION
卷 20, 期 9, 页码 821-826出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gau050
关键词
beta-defensins; sperm; defensin; acrosome reaction; infertility
资金
- MRC
- University of Edinburgh at the MRCIGMM at University of Edinburgh
- NHS Scotland
- University of Dundee
- Medical Research Council [MC_PC_U127527201] Funding Source: researchfish
- MRC [MC_PC_U127527201] Funding Source: UKRI
Recent work in humans and mouse has confirmed the involvement of the host defence beta-defensin peptides in male fertility. We discuss here the work that has implicated beta-defensins in sperm function including the identification of the epididymis as the predominant site of expression of the peptides and the in vivo consequences of mutation and deletion. The potential dual role of these peptides in the regulation of infection and control of sperm maturation is compelling and may combine their antimicrobial activity with the ability of these molecules to interact with cell membrane receptors and modulate ion transport.
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