期刊
MOLECULAR HUMAN REPRODUCTION
卷 21, 期 1, 页码 3-10出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gau082
关键词
cytoplasmic transfer; nuclear transfer; mitochondrial disease; mitochondrial DNA; PGD
资金
- European Research Council under the European Community [210103]
- EU FP7-KBBE-2009-3 Programme [244356]
- EU [312097]
- FECUND and PRIN MIUR founding [2009JE3CHM]
- project MIUR FIRB CNR 'GenHome'
- Bank Foundation Tercas (Teramo, Italy)
- Auckland Medical Research Foundation
- Nurture Foundation
- Maurice and Phyllis Paykel Trust
- Fertility Associates
Mitochondrial DNA(mtDNA) mutations are a relatively common cause of progressive disorders that can be severe or even life-threatening. There is currently no cure for these disorders; therefore recent research has been focused on attempting to prevent the transmission of these maternally inherited mutations. Here we highlight the challenges of understanding the transmission of mtDNA diseases, discuss current genetic management options and explore the use of germ-line reconstruction technologies to prevent mtDNA diseases. In particular we discuss their potential, indications, limitations and possible safety concerns.
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