期刊
MOLECULAR HUMAN REPRODUCTION
卷 21, 期 4, 页码 330-338出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gau114
关键词
High Mobility Group A proteins; side population; human myometrium; uterine leiomyomas; somatic stem cells
资金
- Spanish Ministry of Science and Innovation [SAF 2012-31017, SAF 2012-39732]
- Regional Valencian Ministry of Education [PROMETEOII/2013/018]
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stem cells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cells using in vitro and in vivo approaches. Our work demonstrates that the truncated/short form of HMGA2 induces myometrial cell transformation toward putative tumor-initiating leiomyoma cells and opens up new possibilities to understand the origin of leiomyomas and the development of new therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据