期刊
MOLECULAR HUMAN REPRODUCTION
卷 19, 期 12, 页码 828-837出版社
OXFORD UNIV PRESS
DOI: 10.1093/molehr/gat065
关键词
androgen; folliculogenesis; stroma; angiogenesis; polycystic ovary syndrome
资金
- Medical Research Council UK [RRAK 16242]
- National Institutes of Health [U54HD076188]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPIR)
- MRC [MR/J011592/1] Funding Source: UKRI
- Medical Research Council [MR/J011592/1] Funding Source: researchfish
In women, ovary and adrenal gland produce androgens. Androgens are essential drivers of the primordial to antral follicle development, prior to serving as substrate for estrogen production in the later stages of folliculogenesis. Androgens play a crucial role in the follicularstromal intertalk by fine tuning the extracellular matrix and vessel content of the ovarian stroma. Local auto-and paracrine factors regulate androgen synthesis in the pre-antral follicle. Androgen excess is a hallmark of polycystic ovary syndrome and is a key contributor in the exaggerated antral follicle formation, stromal hyperplasia and hypervascularity. Hyperandrogenaemia overrides the follicularstromal dialog, resulting in follicular arrest and disturbed ovulation. On the other hand, androgen deficiency is likely to have a negative impact on fertility as well, and further research is needed to examine the benefits of androgen-replacement therapy in subfertility.
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