期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 505, 期 -, 页码 1248-1258出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2014.02.055
关键词
Arsenic; Well water; Toenails; Body burden; Geology; Geostatistical modelling
资金
- Canadian Partnership against Cancer and Health Canada
- Canadian Cancer Society [19989]
Arsenic is a naturally occurring class 1 human carcinogen that is widespread in private drinking water wells throughout the province of Nova Scotia in Canada. In this paper we explore the spatial variation in toenail arsenic concentrations (arsenic body burden) in Nova Scotia. We describe the regional distribution of arsenic concentrations in private well water supplies in the province, and evaluate the geological and environmental features associated with higher levels of arsenic in well water. We develop geostatistical process models to predict high toenail arsenic concentrations and high well water arsenic concentrations, which have utility for studies where no direct measurements of arsenic body burden or arsenic exposure are available. 892 men and women who participated in the Atlantic Partnership for Tomorrow's Health Project provided both drinking water and toenail clipping samples. Information on socio-demographic, lifestyle and health factors was obtained with a set of standardized questionnaires. Anthropometric indices and arsenic concentrations in drinking water and toenails were measured. In addition, data on arsenic concentrations in 10,498 private wells were provided by the Nova Scotia Department of Environment We utilised stepwise multivariable logistic regression modelling to develop separate statistical models to: a) predict high toenail arsenic concentrations (defined as toenail arsenic levels 0.12 mu g g(-1)) and b) predict high well water arsenic concentrations (defined as well water arsenic levels 5.0 mu g L-1). We found that the geological and environmental information that predicted well water arsenic concentrations can also be used to accurately predict toenail arsenic concentrations. We conclude that geological and environmental factors contributing to arsenic contamination in well water are the major contributing influences on arsenic body burden among Nova Scotia residents. Further studies are warranted to assess appropriate intervention strategies for reducing arsenic body burden among human populations. (C) 2014 Elsevier B.V. All rights reserved.
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