期刊
MOLECULAR DIVERSITY
卷 17, 期 3, 页码 525-536出版社
SPRINGER
DOI: 10.1007/s11030-013-9450-1
关键词
Pyrido[2,3-d]pyrimidines; 2-Aryl acrylates; Michael addition; 4-Oxopyrido[2,3-d]pyrimidines; 6-Aminopyrimidine-4(3H)-ones
类别
资金
- Spanish Ministerio de Economia y Competividad [SAF2010-C21617-C02]
- IQS
A one step general synthetic methodology for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-diones (17{} () and 20{} ()) is described. This methodology is based on reacting a 2-aryl-substituted acrylate (16{}) with the corresponding 6-aminopyrimidin-4(3-one (13 (; 19 ()) in presence of a base under microwave irradiation. The resulting pyrido[2,3-]pyrimidines present an aryl substituent at position C6, precisely the one directly related to the biological activity of such heterocycles. These protocols have been extended to other 2-alkyl-substituted and 3-alkyl (or aryl)-substituted acrylates but with lower yields.
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