期刊
MOLECULAR DIVERSITY
卷 18, 期 1, 页码 195-202出版社
SPRINGER
DOI: 10.1007/s11030-013-9492-4
关键词
Ionic liquid support; Parallel synthesis; Piperazine derivatives; Insecticidal activity
类别
资金
- NSFC [20972052]
- National Basic Research Program of China (973 Program) [2010CB126101]
- National Key Technology R and D Program [2011BAE06B05-4]
With the purpose of extending our efforts on the search and synthesis of new insecticides with novel acting modes, a series of novel 4-(2-(4-(pyridin-2-yl)piperazin-1-yl)ethoxy)aniline derivatives were designed based on classical serotonin receptor ligands and synthesized through the rapid ionic liquid-supported parallel synthesis with yields up to 88 %. These products were purified through the convenient washing with appropriate solvents and isolated in good yield. In addition, 27 amide or urea derivatives of anilines were also prepared. Bioassay data showed that some of the synthesized compounds displayed selective insecticidal bioactivities against tested pests.
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