期刊
MOLECULAR DIVERSITY
卷 15, 期 2, 页码 361-372出版社
SPRINGER
DOI: 10.1007/s11030-010-9297-7
关键词
GABA(A) receptor modulators; HPLC-based activity profiling; 8-Lavandulyl flavonoids; Sophora flavescens; Fabaceae
类别
资金
- Swiss National Science Foundation [31600-113109, 205321-116157/1]
- Steinegg-Stiftung, Herisau
- Fonds zur Forderung von Lehre und Forschung, Basel
- FWF [P19614-B11]
An EtOAc extract from the roots of Sophora flavescens (Kushen) potentiated gamma-aminobutyric acid (GABA)-induced chloride influx in Xenopus oocytes transiently expressing GABA(A) receptors with subunit composition, alpha (1) beta (2) gamma (2S). HPLC-based activity profiling of the extract led to the identification of 8-lavandulyl flavonoids, kushenol I, sophoraflavanone G, (-)-kurarinone, and kuraridine as GABA(A) receptor modulators. In addition, a series of inactive structurally related flavonoids were characterized. Among these, kushenol Y (4) was identified as a new natural product. The 8-lavandulyl flavonoids are first representatives of a novel scaffold for the target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据