期刊
MOLECULAR DIVERSITY
卷 14, 期 4, 页码 767-776出版社
SPRINGER
DOI: 10.1007/s11030-009-9221-1
关键词
Thiazolidin-4-ones; 2-aminoimidazoles; Imidazolylthiazolidins; Antiviral activity; Cytostatic activity; MCR; 3CCR; Microwave-assisted organic synthesis
类别
资金
- Katholieke Universiteit Leuven
- Geconcerteerde Onderzoeksacties (GOA) of the K.U.Leuven [05/19]
- F.W.O. (Fund for Scientific Research-Flanders (Belgium))
- IRO (Interfacultaire Raad voor Ontwikkelingssamenwerking)
The synthesis and biological activity of a hitherto unknown class of compounds, the imidazolylthiazolidin-4-ones, are described. A two-step procedure has been elaborated starting from our previously described 2-aminoimidazoles. The application of microwave irradiation has been proven to be beneficial for the condensation of the imine with mercaptoacetic acid leading to the formation of imidazolylthiazolidin-4-ones. None of the compounds showed antiviral activity at subtoxic concentrations. Several compounds displayed a moderate cytostatic activity. These data form the basis for further improvement of the potential antiproliferative activity of this class of compounds.
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