期刊
MOLECULAR DIVERSITY
卷 14, 期 3, 页码 411-424出版社
SPRINGER
DOI: 10.1007/s11030-009-9195-z
关键词
Hydrogen autotransfer; Alcohols as electrophiles; Atom efficiency processes; Multicomponent catalysis
A hydrogen autotransfer reaction has been applied to the alpha-alkylation of ketones, with primary alcohols as the electrophilic component, either under homogeneous (using a Ru complex as catalyst) or under heterogeneous (using Ni nanoparticles) conditions. This process is both very efficient (concerning atom economy) and ecologically friendly (water as the only by-product generated). On the other hand, three multicomponent reactions, namely, the Strecker reaction (without any catalyst), the aza-Sakurai process (catalyzed by ferrite), and the addition of in situ generated Zn enolates to chiral sulfinylimines (catalyzed by Cu), have proven to be very efficient in the generation of a diversity of polyfunctionalized molecules.
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