期刊
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
卷 523, 期 -, 页码 82-96出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15421401003724126
关键词
Biocompatibility; collagen-doxycycline matrices; endothelial cells
资金
- Romanian Academy
- Ministry of Research and Education, Romania [71-147/2007]
The aim of this study was to test the biocompatibility between collagen-doxycycline matrices with various porosities and human endothelial cells. Collagen matrices were prepared by freeze-drying process. The crosslinking degree of collagen matrices was evaluated by FT-IR spectroscopy, the matrices morphology by SEM microscopy. The biocompatibility of collagen matrices with endothelial cells was monitored byfluorescence and transmission electron microscopy. We found that the three-dimensional structures of matrix with 1.2% collagen, 0.2% doxycycline crosslinked with 0.25% glutaraldehyde was optimal in terms of biodegradability, morphology and endothelial cells biocompatibility indicating the use of these scaffolds in tissueengineering.
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