期刊
MOLECULAR CELL
卷 71, 期 3, 页码 389-397出版社
CELL PRESS
DOI: 10.1016/j.molcel.2018.07.017
关键词
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资金
- Blavatnik Family Foundation
- Else Kroner-Fresenius Foundation
- Scleroderma Research Foundation
- Howard Hughes Medical Institute
Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories based on kinetics of induction, cell-type and signal specificity, and duration of the response. Here we discuss the structure of transcription programs and suggest a basic framework to categorize gene expression programs based on characteristics related to their control mechanisms. We also discuss possible evolutionary implications of this framework.
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