期刊
MOLECULAR CELL
卷 53, 期 4, 页码 549-561出版社
CELL PRESS
DOI: 10.1016/j.molcel.2014.01.006
关键词
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资金
- Spanish Ministry of Economy and Competitiveness [BFU2012-33503, FEDER, BFU2011-26722]
- Fundacion Marcelino Botin (FMB)
- Consolider Ingenio programme [CSD2007-0015]
- National Institutes of Health
- Deutsche Forschungsgemeinschaft
- ICREA Academia award (Generalitatde Catalunya)
Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon environmental changes. Upon osmostress, hundreds of stress-responsive genes are induced by the stress-activated protein kinase (SAPK) p38/Hog1. Using whole-genome tiling arrays, we found that Hog1 induces a set of lncRNAs upon stress. One of the genes expressing a Hog1-dependent lncRNA in antisense orientation is CDC28, the cyclin-dependent kinase 1 (CDK1) that controls the cell cycle in yeast. Cdc28 lncRNA mediates the establishment of gene looping and the relocalization of Hog1 and RSC from the 3' UTR to the +1 nucleosome to induce CDC28 expression. The increase in the levels of Cdc28 results in cells able to reenter the cell cycle more efficiently after stress. This may represent a general mechanism to prime expression of genes needed after stresses are alleviated.
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