期刊
MOLECULAR CELL
卷 43, 期 6, 页码 892-903出版社
CELL PRESS
DOI: 10.1016/j.molcel.2011.07.024
关键词
-
资金
- Burroughs Wellcome Fund
- Alfred Bressler Scholars Fund
- Starr Cancer Consortium [I3-A139]
- National Institutes of Health [R01-GM083300]
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the RNase ill enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that generate functional microRNAs have emerged. We review here the many Drosha-independent and Dicer-independent microRNA biogenesis strategies characterized over the past few years. Beyond reflecting the flexibility of small RNA machineries, the existence of noncanonical pathways has consequences for interpreting mutants in the core microRNA machinery. Such mutants are commonly used to assess the consequences of total microRNA loss, and indeed, they exhibit many overall phenotypic similarities. Nevertheless, ongoing studies reveal a growing number of settings in which alternative microRNA pathways contribute to distinct phenotypes among core microRNA biogenesis mutants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据