期刊
MOLECULAR CELL
卷 36, 期 6, 页码 924-931出版社
CELL PRESS
DOI: 10.1016/j.molcel.2009.12.011
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R37 CA025417-31, P01 CA112181, R37 CA025417, P01 CA112181-04] Funding Source: Medline
Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.
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