期刊
MOLECULAR CELL
卷 36, 期 6, 页码 970-983出版社
CELL PRESS
DOI: 10.1016/j.molcel.2009.12.001
关键词
-
资金
- Abramson Family Cancer Center at the University of Pennsylvania [CA01520]
- NIH [DK58044, DK54937, T32 HL007150]
- Cold Spring Harbor President's Council
Mixed lineage leukemia (MILL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates active transcription in dividing cells, we investigated its role during M phase of the cell cycle. Unlike other chromatin-modifying enzymes examined, we found that MILL associates with gene promoters packaged within condensed mitotic chromosomes. Genomewide location analysis identified a globally rearranged pattern of MLL occupancy during mitosis in a manner favoring genes that were highly transcribed during interphase. Knockdown experiments revealed that MLL retention at gene promoters during mitosis accelerates transcription reactivation following mitotic exit: MLL tethers Menin, RbBP5, and ASH2L to its occupied sites during mitosis, but is dispensable for preserving histone H3K4 methylation. These findings implicate mitotic bookmarking as a component of Trithorax-based gene regulation, which may facilitate inheritance of active gene expression states during cell division.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据