期刊
MOLECULAR CELL
卷 32, 期 1, 页码 1-9出版社
CELL PRESS
DOI: 10.1016/j.molcel.2008.08.017
关键词
-
资金
- NIGMS NIH HHS [R01 GM035463-22, R01 GM035463-23, R01 GM035463] Funding Source: Medline
Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity. These modes of regulation could be used to establish cell-type-specific insulator activity that is epigenetically inherited along a cell and/or organismal lineage. This review will discuss the evidence for epigenetic inheritance and regulation of insulator function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据