期刊
MOLECULAR CARCINOGENESIS
卷 49, 期 10, 页码 851-861出版社
WILEY
DOI: 10.1002/mc.20674
关键词
skin; snail family transcription factors; ultraviolet rays; wound healing; skin neoplasms
资金
- National Institutes of Health [R01 CA089216, R21 AR054361, P30 CA16672, P30 ES007784, R01 GM079381, T32 CA09480]
The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound healing, skin cancer, and sunburn. Slug is expressed in basal keratinocytes and hair follicles where it is important in maintaining epidermal homeostasis. Slug also helps coordinate the skin response to exogenous stimuli. Slug is rapidly induced by a variety of growth factors and injurious agents and Slug controls, directly or indirectly, a variety of keratinocyte responses, including changes in differentiation, adhesion, motility, and production of inflammatory mediators. Slug thus modulates the interactions of the keratinocyte with its environment and with surrounding cells. The function of Slug in the epidermis appears to be distinct from that of the closely related Snail transcription factor. (C) 2010 Wiley-Liss, Inc.
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