期刊
MOLECULAR CARCINOGENESIS
卷 48, 期 4, 页码 309-318出版社
WILEY
DOI: 10.1002/mc.20512
关键词
alternative DNA structures; DNA repeats; DNA damage checkpoints; replication; chromosomal fragility
资金
- NIH [GM60987, GM063066]
DNA sequences that are prone to adopting non-B DNA secondary structures are associated with hotspots of genomic instability. The fine mechanisms by which alternative DNA structures induce phenomena such as repeat expansions, chromosomal fragility, or gross chromosomal rearrangements are under intensive studies. It is well established that DNA damage checkpoint responses play a crucial role in maintaining a stable genome. It is far less clear, however, whether and how the checkpoint machinery responds to alternative DNA structures. This review discusses the role of the interplay between DNA damage checkpoints and alternative DNA structures in genome maintenance. (C) 2009 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据