期刊
MOLECULAR CARCINOGENESIS
卷 48, 期 9, 页码 790-800出版社
WILEY
DOI: 10.1002/mc.20523
关键词
genetic susceptibility; oral cancer risk; tobacco use; genotype combination
资金
- DBT [BT/PR/5524/Med/14/649/2004, BT/01/COE/05/04]
- CSIR [CMM 0016, JAP 001]
Polymorphisms at loci controlling cellular processes such as cell cycle, DNA repair, and apoptosis may modulate the risk of cancer. We examined the association of two linked polymorphisms (G4C 14-A4T14) at p73 and one polymorphism (309G > T) at MDM2 promoter with the risk of leukoplakia and oral cancer. The p73 and MDM2 genotypes were determined in 197 leukoplakia patients, 310 oral cancer patients and in 348 healthy control subjects. The p73 GC/AT genotype increased the risk of leukoplakia (OR = 1.6, 95% Cl = 1.1-2.3) and oral cancer (OR = 2.4, 95% Cl = 1.7-3.3) but the 309G > T MDM2 polymorphism independently could not modify the risk of any of the diseases. Stratification of the study population into subgroups with different tobacco habits showed that the risk of the oral cancer is not modified further for the individuals carrying p73 risk genotype. However, leukoplakia patients with smokeless tobacco habit showed increased risk with combined GC/AT and AT/AT (OR = 3.0, 95% Cl = 1.3-7.0) genotypes. A combined analysis was done with our previous published data on p53 codon 72 pro/arg polymorphism. Analysis of pair wise genotype combinations revealed increase in risk for specific p73-MDM2 and p73-p53 genotype combinations. Finally, the combined three loci analyses revealed that the presence of at least one risk allele at all three loci increases the risk of both leukoplakia and oral cancer. (C) 2009 Wiley-Liss, Inc.
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