期刊
SCIENCE CHINA-LIFE SCIENCES
卷 58, 期 11, 页码 1111-1125出版社
SCIENCE PRESS
DOI: 10.1007/s11427-015-4953-x
关键词
systemic lupus erythematosus; B cell; pathogenesis; target therapy
类别
Systemic lupus erythematosus (SLE) is a debilitating autoimmune disease that can involve multi-organs. B cells play a central role in the immunopathogenesis via antibody-dependent and antibody-independent ways. Excessive autoantibodies production, hyperresponsiveness and prolonged survival of autoreactive B cells are characteristics of SLE. In this article, mechanisms of self-tolerance loss of B cells and promising B cell-targeting therapies in lupus are reviewed and discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据