期刊
MOLECULAR CANCER RESEARCH
卷 16, 期 11, 页码 1665-1675出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-18-0284
关键词
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资金
- National Nature Science Foundation of China [81001178]
- Science Foundation of Hebei Province [16967788D]
Circular RNA ciRS-7 has been reported to act as a competing endogenous RNA (ceRNA) of the miRNA miR-7, resulting in reduced miR-7 activity and increased miR-7-targeted transcripts. However, it is unknown if ciRS-7 harbors other miRNAs with regulatory roles in triple-negative breast cancer (TNBC). The present study determined that the expression of ciRS-7 in TNBC clinical specimens and representative cells is significantly higher than other breast cancer subtypes. Functionally, downregulation of ciRS-7 inhibited cell migration and invasion of TNBC cells. Knockdown of ciRS-7 expression also inhibited the liver and lung metastasis of TNBC cells in vivo. Mechanistic studies revealed that ciRS-7 contains 20 miR-1299-binding sites and func-tions as a ceRNA of miR-1299 in TNBC cells. High expression of ciRS-7 maintains the high migration and invasion properties of TNBC cells by acting as a ceRNA of miR-1299 to enhance the expression of matrix metalloproteinases family members (MMP). Implications: Circular RNA ciRS-7 is highly expressed in TNBC tumor specimens and cells, and its downregulation inhibits cell migration and invasion of TNBC cells in vitro and in vivo. In addition, ciRS-7 functions as a ceRNA of miR1299 to enhance the expression of MMPs, which maintains the high migration and invasion properties of TNBC cells. (C) 2018 AACR.
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