期刊
MOLECULAR CANCER RESEARCH
卷 9, 期 8, 页码 985-996出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-10-0365
关键词
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资金
- Sanford Research/USD, Department of Defense [PC073887, PC073643]
- South Dakota Governor's Cancer
Protein kinase D1 (PKD1) is a serine-threonine kinase that regulates various functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. In normal cells, this protein plays key roles in multiple signaling pathways by relaying information from the extracellular environment and/or upstream kinases and converting them into a regulated intracellular response. The aberrant expression of PKD1 is associated with enhanced cancer phenotypes, such as deregulated cell proliferation, survival, motility, and epithelial mesenchymal transition. In this review, we summarize the structural and functional aspects of PKD1 and highlight the pathobiological roles of this kinase in cancer. Mol Cancer Res; 9(8); 985-96. (C)2011 AACR.
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