期刊
MOLECULAR CANCER
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-018-0888-8
关键词
circRNAs; Microarray; Biomarker; Exosomes; Plasma
资金
- Natural Science of Jiangsu Province [BK20151087]
- Development of Medical Science and Technology Foundation of Nanjing [ZKX14035]
CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.
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