期刊
MOLECULAR CANCER
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-018-0869-y
关键词
Exosome; Extracellular vesicles; Hypoxia; Cancer
资金
- Natural Science Foundation of Jiangsu Province [BK20171484]
- Project of Invigorating Health Care through Science, Technology, and Education (Jiangsu Provincial Medical Youth Talent) [QNRC2016856]
- National Natural Science Foundation of China [81672896]
- Summit of the Six Top Talents Program of Jiangsu Province [2017-WSN-179]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_1483]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [JX10231801]
Purpose: Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. Methods: The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms. Results: Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system. Conclusions: These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.
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