期刊
MOLECULAR CANCER
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1476-4598-13-40
关键词
IL-1 beta; NF-kappaB; miR-425; PTEN; Gastric cancer
资金
- National Natural Science Foundation of China [81101515, 81201897, 81201912]
- Program of Shanghai Municipal Education Commission [12YZ052, shjdy027]
Overexpression of the proinflammatory cytokine IL-1 beta is associated with diverse diseases, including cancer. Alteration of microRNAs has been observed in cancer cells exposed to proinflammatory cytokines, yet their function in inflammation stress remains elusive. Here, we show that IL-1 beta induces the upregulation of miR-425, which negatively regulates phosphatase and tensin homolog expression by targeting its 3 ' UTR. An increase in miR-425 depends on IL-1 beta-induced N Gamma-kappaB activation, which enhances miR-425 gene transcription upon IL-1 beta induction. Consequently, repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation, which is required to protect cells from cisplatin-induced apoptosis. Taken together, our data support a critical role for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1 beta induction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据