期刊
MOLECULAR CANCER
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1476-4598-13-234
关键词
LOXL4; miR-193a-3p; Chemoresistance; Bladder cancer; Oxidative stress pathway
资金
- 973 National Key Fundamental Research Program of China [2010CB912802]
- National Natural Science Foundation of China [81472638, 30921140312, 81171996, 81272289, 81200975]
- Anhui Provincial Natural Science Foundation [1208085QH166]
- Wujieping Medical Foundation [320.6750.13252]
- 973 National Key Fundamental Research Program of China [2010CB912802]
- National Natural Science Foundation of China [81472638, 30921140312, 81171996, 81272289, 81200975]
- Anhui Provincial Natural Science Foundation [1208085QH166]
- Wujieping Medical Foundation [320.6750.13252]
Background: Chemoresistance is a major obstacle to the curative cancer chemotherapy and presents one of the most formidable challenges in both research and management of cancer. Results: From the detailed studies of a multi-chemosensitive (5637) versus a chemoresistant (H-bc) bladder cancer cell lines, we showed that miR-193a-3p [GenBank: NR_029710.1] promotes the multi-chemoresistance of bladder cancer cells. We further demonstrated that lysyl oxidase-like 4 (LOXL4) gene [GenBank: NM_032211.6] is a direct target of miR-193a-3p and executes the former's impact on bladder cancer chemoresistance. The Oxidative Stress pathway activity is drastically affected by a forced reversal of miR-193a-3p or LOXL4 levels in cell and may act at the downstream of LOXL4 gene to relay the miR-193a-3p's impact on the multi-chemoresistance in both cultured cells and the tumor xenografts in nude mice. Conclusions: In addition to a new mechanistic insight, our results provide a set of the essential genes in this newly identified miR-193a-3p/LOXL4/Oxidative Stress axis as the diagnostic targets for a guided anti-bladder cancer chemotherapy.
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