期刊
MOLECULAR CANCER
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1476-4598-12-107
关键词
Alternative splicing; Cell adhesion molecules; Epithelial-mesenchymal transition; Metastatic cascade; Non-coding RNAs; Small molecule compounds; Transcription factors
资金
- Bundesministerium fur Bildung und Forschung (BMBF) [RUS 10/022]
- Russian Ministry of Science [14.512.11.0024, 14.512.11.0083]
Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.
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