期刊
MOLECULAR CANCER
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1476-4598-8-69
关键词
-
资金
- Beca Ortiz de Landazuri 2006, Departamento de Salud-Gobierno de Navarra
- Fondo de Investigacion Sanitaria (FIS, Spain) [PI070602, PI070608, PI060003, CP07/00215, RD06/0020]
- Junta de Andalucia [0386/2006, 0004/2007]
- Asociacion Medicina e Investigacion (AMI)
- UTE project CIMA
The development of Imatinib Mesylate (IM), the first specific inhibitor of BCR-ABLI, has had a major impact in patients with Chronic Myeloid Leukemia (CML), establishing IM as the standard therapy for CML. Despite the clinical success obtained with the use of IM, primary resistance to IM and molecular evidence of persistent disease has been observed in 20-25% of IM treated patients. The existence of second generation TK inhibitors, which are effective in patients with IM resistance, makes identification of predictors of resistance to IM an important goal in CML. In this study, we have identified a group of 19 miRNAs that may predict clinical resistance to IM in patients with newly diagnosed CML.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据