期刊
MOLECULAR BIOSYSTEMS
卷 10, 期 7, 页码 1749-1752出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mb00150h
关键词
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资金
- National Institute of Health [R01 CA101864]
We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite and the neighboring CpG sites. Our results provided important new knowledge about the implications of the 5-methylcytosine oxidation products in maintenance cytosine methylation.
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