期刊
MOLECULAR BIOSYSTEMS
卷 10, 期 11, 页码 2775-2782出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mb00338a
关键词
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资金
- National Public Sector [201207009]
- National Natural Science Foundation of China [81173116, 81403375]
microRNAs (miRNAs) are a class of small non-coding RNA molecules consisting of 19-22 nucleotides that play an important role in a variety of biological processes, including development, differentiation, apoptosis, cell proliferation and cellular senescence. A growing body of evidence suggests that miRNAs are aberrantly expressed in human cardiac diseases and they play a significant role in the initiation and development. Recently, studies revealed that microRNA-1 (miR-1) was frequently downregulated in various types of cardiac diseases. Here we review recent findings on the aberrant expression and functional significance of miR-1.
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