期刊
MOLECULAR BIOSYSTEMS
卷 6, 期 4, 页码 721-728出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b908047c
关键词
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资金
- National Library of Medicine (MYG)
- NIGMS [R01 GM076680-02]
- NIDDK [UO1 DK072473]
- NSF [DBI-0544757, NSF-07140]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076680] Funding Source: NIH RePORTER
Comparative analysis of the complete genome sequences from a variety of poorly studied organisms aims at predicting ecological and behavioral properties of these organisms and helping in characterizing their habitats. This task requires finding appropriate descriptors that could be correlated with the core traits of each system and would allow meaningful comparisons. Using the relatively simple bacterial models, first attempts have been made to introduce suitable metrics to describe the complexity of organism's signaling machinery, which included introducing the bacterial IQ'' score. Here, we use an updated census of prokaryotic signal transduction systems to improve this parameter and evaluate its consistency within selected bacterial phyla. We also introduce a more elaborate descriptor, a set of profiles of relative abundance of members of each family of signal transduction proteins encoded in each genome. We show that these family profiles are well conserved within each genus and are often consistent within families of bacteria. Thus, they reflect evolutionary relationships between organisms as well as individual adaptations of each organism to its specific ecological niche.
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