期刊
MOLECULAR BIOSYSTEMS
卷 5, 期 12, 页码 1713-1719出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b905848f
关键词
-
资金
- Trinity College, Cambridge,
- Cavendish Laboratory
Unusual DNA structures such as four-stranded G-quadruplexes have been found to form in vivo and to play regulatory roles. However, since DNA is normally present as chromatin, with the double helix wrapped around histone proteins, it is unclear how a G-quadruplex could form in such a region. Here, we show that regulatory G-quadruplexes found upstream of transcription start sites are in fact located in a region depleted of nucleosomes, and that in general in both Caenorhabditis elegans and humans, stable G-quadruplexes are located outside nucleosome-bound regions, hence making it easier for them to form in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据