期刊
MOLECULAR BIOSYSTEMS
卷 4, 期 12, 页码 1176-1180出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b808271p
关键词
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资金
- NIH [R01 AI067858, AI074856, R03 AI072510]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R03AI072510, R01AI074856, R01AI067858] Funding Source: NIH RePORTER
Many Gram-negative bacterial pathogens use type III secretion systems (TTSSs) for subverting the normal cellular functions of their target eukaryotic cells. The type III secretion apparatus (TTSA) functions like a syringe to inject proteins through an external needle and into a target cell's membrane and cytosol. The TTSA basal body spans the bacterial inner and outer membranes, and the external needle is topped with a tip complex that controls the secretion and delivery of translocator and effector proteins. Recently solved structures of TTSA proteins have greatly advanced our understanding of shared themes in apparatus assembly and function. In this highlight, the structure--function of TTSA needle and tip complex proteins are described and common themes discussed.
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