期刊
MOLECULAR BIOLOGY REPORTS
卷 42, 期 6, 页码 1039-1047出版社
SPRINGER
DOI: 10.1007/s11033-014-3841-y
关键词
LOX-1; TNF receptors; Atherosclerosis; Nitric oxide; Oxidized-LDL
资金
- Department of Biotechnology, Government of India [BT/PR7678/MED/14/1061/2006]
- CSIR, Government of India
TNF-alpha potently induces LOX-1 expression in THP-1 macrophages at concentrations between 1.25-50 ng/mL. The interplay between the two TNF receptors (TNFR1 and TNFR2) was apparent in the expression pattern of LOX-1 in response to TNF-alpha. Interestingly, R1 signal abrogation depleted both TNFR2 as well as LOX-1 transcript expression, suggesting that TNFR1 holds priority in the relative signaling mechanism between TNFR1 and TNFR2. TNF-alpha was also found to abrogate the oxidized-LDL (ox-LDL) mediated increase in intracellular pool of NO, a known downstream intermediate of LOX-1 pro-inflammatory signaling cascade. At the level of ox-LDL clearance, TNF-alpha inhibited the uptake (scavenging) of ox-LDL via LOX-1. Our study demonstrates the ability of TNF-alpha to enhance the signaling propensity of LOX-1 by increasing its expression and inhibiting its scavenging property.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据