期刊
MOLECULAR BIOLOGY REPORTS
卷 40, 期 9, 页码 5255-5259出版社
SPRINGER
DOI: 10.1007/s11033-013-2625-0
关键词
Cytochrome P450 2A6 (CYP2A6); Polymorphism; Meta-analysis; Lung cancer
资金
- Natural Science Foundation of Anhui Province, China [1308085MH141]
- Department of Education of Anhui Province, China [KJ2011A173]
- Anhui Medical University [2010xkj115]
- Fourth Affiliated Hospital of Anhui Medical University, China
Previous studies concerning the association between cytochrome P450 2A6 (CYP2A6) deletion polymorphism and lung cancer risk provided controversial results. To clarify the precise association, a meta-analysis was performed. The electronic databases PubMed, Chinese Biomedical Database and Chinese National Knowledge Infrastructure Database were searched for case-control studies last updated on June 3, 2012 that investigated CYP2A6 deletion polymorphism and lung cancer risk. The odds ratio (OR) and its respective 95 % confidence interval (95 % CI) were used to measure the strength of association by means of a genetic model free approach. A total of 8 studies including 2,607 cases and 2,595 controls met the inclusion criteria and were subjected to the final analysis. The most appropriate co-dominant model was adopted. Overall, we found that CYP2A6 *1/*1 genotype was associated with an increased risk of lung cancer relative to *4/*4 genotype (OR = 2.65, 95 % CI: 1.84-3.81, P < 0.001). Significant association was also detected among Asians. Publication bias was absent in this meta-analysis. Therefore, our data suggested that the presence of the CYP2A6 *1/*1 might be associated with an increased lung cancer risk, especially for Asians. Further studies well-designed among different ethnicity populations are required.
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