期刊
MOLECULAR BIOLOGY REPORTS
卷 40, 期 5, 页码 3577-3582出版社
SPRINGER
DOI: 10.1007/s11033-012-2431-0
关键词
Hsa-miR-26b; Adipocyte; Adipokines; Tumor necrosis factor-alpha; Interleukin-6; Leptin; Resistin
资金
- National Key Basic Research Program of China [2013CB530604]
- National Natural Science Foundation of China [81170797]
- Natural Science Foundation of Jiangsu Province China [BK2011107]
- Program for Innovative Research Teams of Jiangsu Province [LJ201108]
- Nanjing Technological Development Program [201104013]
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression. Hsa-miR-26b is an intronic miRNA located in the intron of CTDSP1 (carboxy-terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1). In the present study, the expression of hsa-miR-26b was examined during human preadipocyte differentiation. 15 days after induction of differentiation, mature human adipocytes were treated with adipokines. Hsa-miR-26b was differentially expressed during human preadipocyte differentiation. Tumor necrosis factor-alpha (TNF-alpha), leptin and resistin, but not interleukin-6, caused downregulation of hsa-miR-26b expression in adipocytes. These results suggest that the expression of hsa-miR-26b is affected by TNF-alpha, leptin and resistin and that hsa-miR-26b may be an important mediator in regulating the obesity-related insulin sensitivity and inflammatory responses.
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