期刊
MOLECULAR BIOLOGY REPORTS
卷 40, 期 4, 页码 2851-2857出版社
SPRINGER
DOI: 10.1007/s11033-012-2300-x
关键词
Colorectal cancer; Inflammation; Interleukin-1; Cytokines; Polymorphism
资金
- Sectoral Operational Programme Human Resources Development (SOP HRD)
- European Social Fund
- Romanian Government [POSDRU/89/1.5/S/64109]
- [POSDRU/6/1.5/S/8]
- [7603]
Epidemiological and experimental evidence indicates chronic inflammation as a risk factor for colorectal cancer. We investigated whether IL-1B -511C > T (rs16944), IL-1B +3954C > T (rs1143634) and IL1-RN +2018T > C (rs419598) cytokine polymorphisms are correlated with colorectal cancer. Blood samples were obtained from 377 Romanian subjects: 144 patients with sporadic colorectal cancer and 233 healthy controls. Polymorphisms were analyzed by allelic discrimination TaqMan PCR assays with specific probes. The results of our study showed that IL-1RN +2018T > C polymorphism is associated with colorectal cancer. We found that there was a significant difference in the frequency of CC genotype between patients with colorectal cancer and the control group (OR 2.42, 95 % CI: 1.06-5.53, p = 0,034) when TT genotype was used as reference. Furthermore, in a stratified analysis, a positive association was found only for IL-1RN +2018CC genotype, that was limited to early I and II stages (OR 2.72, 95 % CI: 1.05-7.03, p = 0,033). We did not find any association between any of the IL-1B polymorphisms and colorectal cancer. In conclusion this study found that IL-1RN +2018T > C polymorphism is associated with colorectal cancer, mainly for localized disease.
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