期刊
MOLECULAR BIOLOGY REPORTS
卷 39, 期 3, 页码 2615-2624出版社
SPRINGER
DOI: 10.1007/s11033-011-1014-9
关键词
Prostate cancer; Androgen receptor gene; CAG repeat polymorphism; Risk; Meta-analysis
资金
- Shanghai Jiao Tong University
- Youth Foundation of Shanghai Municipal Health Bureau [2010Y050]
- Shanghai Chen Guang Project [09CG12]
- Shanghai Rising Star Program [11QA1405500]
- Natural Science Foundation of Shanghai Municipality [09ZR1426200]
- National Science Foundation for Young Scientists of China [30900808]
The association between the polymorphic CAG repeat in androgen receptor gene (AR) and prostate cancer susceptibility has been studied extensively. However, the results are contradictory. The purpose of our meta-analysis was to investigate whether CAG repeat related to prostate cancer risk and had genetic heterogeneity across different geographic regions and study designs. Random-effects model was performed irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate. Publication bias was assessed by the fail-safe number and Egger's test. There were 16 (patients/controls: 2972/3792), 19 (3835/4908) and 12 (3372/2631) study groups for comparisons of >= 20, 22 and 23 repeats of CAG sequence, respectively. Compared with CAG repeat <20, 22 or 23, carriers of >= 20, 22 or 23 repeats had 21% (95% CI: 0.61-1.02; P = 0.076), 5% (95% CI: 0.81-1.11; P = 0.508) and 5% (95% CI: 0.76-1.20; P = 0.681) decreased risk of prostate cancer. After classifying studies by geographic areas, carriers of >= 20 repeats had 11% decreased risk in populations from USA, 53% from Europe, and 20% from Asia (P > 0.05), whereas comparison of >= 23 repeats with others generated a significant prediction in European populations (OR = 1.17; P = 0.039). Stratification by study designs revealed no material changes in risk estimation. Meta-regression analysis found no significant sources of between-study heterogeneity for age, study design and geographic region for all comparisons. There was no identified publication bias. Taken together, our results demonstrated that AR CAG repeat polymorphism with >= 20 repeats might confer a protective effect among the prostate cancer patients with 45 years older but not all the prostate cancer patients.
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