期刊
MOLECULAR BIOLOGY REPORTS
卷 39, 期 2, 页码 1087-1093出版社
SPRINGER
DOI: 10.1007/s11033-011-0835-x
关键词
DRAM2; DRAM; Autophagy; Starvation; LC3
资金
- National Research Foundation of Korea
- Korean Government [2010-0009567, 2009-0065887]
- Mid-career Researcher Program [RO1-2008-000-20253-0]
- National Research Foundation of Korea [2009-0065887, 2010-0009567] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Autophagy is a membrane trafficking process involved in intracellular degradation and recycling in eukaryotic cells. DRAM2 (damage-regulated autophagy modulator 2) is a homologue of DRAM that regulates p53-mediated cell death. As its name implies, DRAM expression induces autophagy in a p53-dependent manner; however, the role of DRAM2 in autophagy is not clear. In this study, we report that DRAM2 expression contributes to autophagy induction. Overexpression of DRAM2 induces cytoplasmic GFP-LC3 punctuates, and increases the level of endogenous LC3-II. Moreover, the silencing of endogenous DRAM2 interferes with starvation-induced autophagy. Thus, we propose that DRAM2 as well as DRAM are involved in autophagy.
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