期刊
SCIENCE
卷 349, 期 6248, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1255555
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资金
- UK Medical Research Council [U105184291]
- Association pour la Recherche sur Alzheimer
- MRC [MC_U105184291] Funding Source: UKRI
- Medical Research Council [MC_U105184291] Funding Source: researchfish
The pathological assembly of Ab, tau, and alpha-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular deposits of Ab and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of alpha-synuclein make up the Lewy pathology of Parkinson's disease. Most cases of disease are sporadic, but some are inherited in a dominant manner. Mutations frequently occur in the genes encoding Ab, tau, and alpha-synuclein. Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific regions of the brain during the process of Alzheimer's and Parkinson's diseases, from where it spreads to other areas.
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