期刊
SCIENCE
卷 347, 期 6217, 页码 78-81出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1260825
关键词
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资金
- Virginia and D. K. Ludwig Fund for Cancer Research
- Lustgarten Foundation for Pancreatic Cancer Research
- Sol Goldman Center for Pancreatic Cancer Research
- NIH [P30-CA006973, R37-CA43460, RO1-CA57345, P50-CA62924]
Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue's homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells. This is important not only for understanding the disease but also for designing strategies to limit the mortality it causes.
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