期刊
MOLECULAR BIOLOGY REPORTS
卷 36, 期 8, 页码 2345-2351出版社
SPRINGER
DOI: 10.1007/s11033-009-9456-z
关键词
Propofol; Polymicrobial sepsis; Tumor necrosis factor alpha; Interleukin 6; Nuclear factor kappaB
资金
- Natural Science Foundation of Hubei Province of China [2002AB147]
- Institutional Animal Care and Use Committee, Wuhan University
Nuclear factor kappa B (NF-kappa B) plays a central role in regulating the transcription of several genes associated with sepsis/septic shock. Therefore, the author investigated the effects of propofol on the plasma tumor necrosis factor alpha and interleukin 6 (TNF-alpha and IL-6) levels and NF-kappa B activation during polymicrobial sepsis in rats. Male Sprague-Dawlay rats were subjected to cecal ligation and puncture (CLP, a model of polymicrobial sepsis) or sham operation. The animals were randomly assigned into four equal groups (n = 10): sham CLP group, CLP group, PPF (propofol) I group and PPF II group. Thirty minutes before CLP, propofol (5 and 10 mg kg(-1) h(-1), respectively) was infused continuously through the left femoral vein cannula in PPF I group or PPF II group, CLP group and sham CLP group receiving 0.9% saline only at the rates of 5 ml kg(-1) h(-1). The right femoral artery was cannulated to monitor mean arterial pressure (MAP) and heart rates (HR). CLP produced progressive hypotension and a first increase followed by a decrease in HR. The plasma TNF-alpha and IL-6 levels and the hepatic NF-kappa B activation significantly increased after CLP alone. Compared with CLP group, propofol treatment reversed hypotension, slightly steadied heartbeats, and decreased the plasma TNF-alpha and IL-6 levels, and significantly suppressed NF-kappa B activation. Propofol has inhibited the hepatic NF-kappa B activition and the pro-inflammatory cytokine response during polymicrobial sepsis in rats.
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