期刊
MOLECULAR BIOLOGY REPORTS
卷 36, 期 6, 页码 1247-1250出版社
SPRINGER
DOI: 10.1007/s11033-008-9304-6
关键词
TGF-beta family; TGF-beta; Activin; BMP; Melanin; Melanoma
资金
- Japan Society for the Promotion of Science [17580262, 18580299]
- Foundation for Japanese Private School Promotion
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Grants-in-Aid for Scientific Research [17580262, 18580299] Funding Source: KAKEN
Effects of representative members of the transforming growth factor-beta (TGF-beta) family, TGF-beta 1, activin A and BMP-2, on melanin content and expression of pigment-producing enzymes were examined in B16 melanoma cells. Treatment with TGF-beta 1 or activin A but not with BMP-2 significantly decreased melanin content and expression of Tyrosinase and Tyrp-1, suggesting an inhibitory effect of TGF-beta 1 and activin A on melanin synthesis. TGF-beta 1 completely inhibited melanin synthesis induced by alpha-melanin stimulating hormone (alpha-MSH), whereas activin A only slightly did. As compared with parental B16 cells, the inhibitory effects of TGF-beta 1 and activin A on melanin content were relative smaller in B16 F10 cells, a subline of B16 cells that contain more pigment. The present study indicates that in addition to TGF-beta, activin negatively regulates melanogenesis in the absence of alpha-MSH, but that the activity in the presence of alpha-MSH was slightly different between TGF-beta and activin.
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