期刊
SCIENCE
卷 348, 期 6235, 页码 694-699出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa3662
关键词
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资金
- Bill and Melinda Gates Foundation
- Science and Technology Directorate of the Department of Homeland Security [HSHQDC-12-C-00058]
- RAPIDD program of the Science and Technology Directorate of the Department of Homeland Security
- Fogarty International Center, National Institutes of Health
Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive interannual fluctuations in nonmeasles deaths. This is consistent with recent experimental work that attributes the immunosuppressive effects of measles to depletion of B and T lymphocytes. Our data provide an explanation for the long-term benefits of measles vaccination in preventing all-cause infectious disease. By preventing measles-associated immune memory loss, vaccination protects polymicrobial herd immunity.
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