期刊
SCIENCE
卷 347, 期 6226, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1259038
关键词
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资金
- National Human Genome Research Institute Centers of Excellence in Genomics Science [P50 HG006193]
- Broad Institute Funds
- NIH Pioneer Award
- Klarman Cell Observatory
- HHMI
- Swiss National Science Foundation (SNF)
- Marie Sklodowska-Curie International Outgoing Fellowships
- NIH Training Program in Bioinformatics and Integrative Genomics training grant
- Rothschild Fellowship
- European Molecular Biology Organization fellowship
- Human Frontier Science Program fellowships
- Howard Hughes Medical Institute Gilliam Fellowship for Advanced Study
Protein expression is regulated by the production and degradation of messenger RNAs (mRNAs) and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics so as to build a quantitative genomic model of the differential regulation of gene expression in lipopolysaccharide-stimulated mouse dendritic cells. Changes in mRNA abundance play a dominant role in determining most dynamic fold changes in protein levels. Conversely, the preexisting proteome of proteins performing basic cellular functions is remodeled primarily through changes in protein production or degradation, accounting for more than half of the absolute change in protein molecules in the cell. Thus, the proteome is regulated by transcriptional induction for newly activated cellular functions and by protein life-cycle changes for remodeling of preexisting functions.
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