期刊
MOLECULAR BIOLOGY OF THE CELL
卷 22, 期 2, 页码 179-188出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E10-02-0173
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资金
- Canadian Institutes of Health Research [MOP-81215]
- Canadian Cancer Society [700428]
- Fonds de la Recherche en Sante du Quebec (FRSQ)
Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after telomerase inhibition. We determined whether telomeric recombination can also be promoted by telomere dysfunction. We report for the first time that telomeric recombination can be induced in human telomerase-positive cancer cells with dysfunctional telomeres.
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