期刊
MOLECULAR BIOLOGY OF THE CELL
卷 20, 期 1, 页码 509-520出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E08-03-0274
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资金
- Jesse's Journey Foundation
- Muscular Dystrophy Association
- National Institutes of Health (NIH) [R01 AR49684, R01 AR47973]
- William F. and Jean W. Donaldson Chair at Children's Hospital of Pittsburgh
- Henry J. Mankin Chair at the University of Pittsburgh
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR049684, R01AR047973] Funding Source: NIH RePORTER
Stem cells are classically defined by their multipotent, long-term proliferation, and self-renewal capabilities. Here, we show that increased antioxidant capacity represents an additional functional characteristic of muscle-derived stem cells (MDSCs). Seeking to understand the superior regenerative capacity of MDSCs compared with myoblasts in cardiac and skeletal muscle transplantation, our group hypothesized that survival of the oxidative and inflammatory stress inherent to transplantation may play an important role. Evidence of increased enzymatic and nonenzymatic antioxidant capacity of MDSCs were observed in terms of higher levels of superoxide dismutase and glutathione, which appears to confer a differentiation and survival advantage. Further when glutathione levels of the MDSCs are lowered to that of myoblasts, the transplantation advantage of MDSCs over myoblasts is lost when transplanted into both skeletal and cardiac muscles. These findings elucidate an important cause for the superior regenerative capacity of MDSCs, and provide functional evidence for the emerging role of antioxidant capacity as a critical property for MDSC survival post-transplantation.
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