期刊
SCIENCE
卷 350, 期 6262, 页码 815-820出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad0217
关键词
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资金
- Wellcome Trust [098410/Z/12/Z, 05568/Z/14/Z, 092986/Z]
- Fundacao para a Ciencia e a Tecnologia (Portugal) [FCT] [SFRH/BD/63312/2009]
- Royal Society [05568/Z/14/Z]
- Biotechnology and Biological Sciences Research Council (UK) [BB/IO22414/1]
- Wellcome Trust [098410/Z/12/Z] Funding Source: Wellcome Trust
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63312/2009] Funding Source: FCT
- Biotechnology and Biological Sciences Research Council [BB/I022414/1] Funding Source: researchfish
- BBSRC [BB/I022414/1] Funding Source: UKRI
The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored. We found that mutation of a single miRNA locus (miR-iab4/iab8) in Drosophila larvae affects the animal's capacity to correct its orientation if turned upside down (self-righting). One of the miRNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants, whereas thermogenetic manipulation of SRN activity results in changes in self-righting behavior. Our work thus reveals a miRNA-encoded behavior and suggests that other miRNAs might also be involved in behavioral control in Drosophila and other species.
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