期刊
MOLECULAR BIOLOGY OF THE CELL
卷 19, 期 5, 页码 2051-2058出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E07-09-0930
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资金
- National Institutes of Health [GM31321]
- UT Southwestern Endowed Scholars Program
In nested collagen matrices, human fibroblasts migrate from cell-containing dermal equivalents into surrounding cell-free outer matrices. Time-lapse microscopy showed that in addition to cell migration, collagen fibril flow occurred in the outer matrix toward the interface with the dermal equivalent. Features of this flow suggested that it depends on the same cell motile machinery that normally results in cell migration. Collagen fibril flow was capable of producing large-scale tissue translocation as shown by closure of a similar to 1-mm gap between paired dermal equivalents in floating, nested collagen matrices. Our findings demonstrate that when fibroblasts interact with collagen matrices, tractional force exerted by the cells can couple to matrix translocation as well as to cell migration.
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